A - Incorrect: The use of the preposition as makes the sentence confusing. The pronoun that should not be used to refer to people.
B - Correct: The relative pronoun who is correctly used to refer to humans, and the time indication in childhood is correctly used to describe when the people have been crippled. The word once is much more concise than the phrase at one time.
C - Incorrect: The relative pronoun that should not refer to humans. The use of the preposition as makes the sentence confusing.
D - Incorrect: The sentence is wordy, changes the meaning of the original sentence, and is stylistically less preferable.
E - Incorrect: This sentence is wordy and awkward.